Journal: Bioactive Materials

Article Title: Bioaugmented design and functional evaluation of low damage implantable array electrodes

doi: 10.1016/j.bioactmat.2024.12.033

Figure Lengend Snippet: Neural microfilament array electrode model structural design and site distribution optimization. A) Schematic design of bio-enhanced microfilament array electrode structure. B) Geometric model of neuronal static discharge (Model size of 1 × 1 × 1 mm 3 , neuron spacing of 100 μm, neuron firing frequency of 7Hz). C) Calculation of potential distribution at various distances from the neuron. D) i) Simulation of signal collection coverage for array electrodes at different spacings (red circles indicate the collection range of a single site within the array). ⅱ) Receivable signal coverage area for different array spacing electrodes. ⅲ) Overlap of receivable signal coverage for different array spacing electrodes. ⅳ) Minimum number of acquisition sources for different array spacing electrodes.

Article Snippet: Electrophysiological signals from electrodes were collected using a neural electrode electrophysiological signal acquisition system (Zeus 128-channel system, Nanjing Bio-signal, China), which allows for high-precision surgical implantation of electrodes in small animals and comprehensive monitoring of acute/chronic signals across 128 channels.

Techniques:

Journal: Bioactive Materials

Article Title: Bioaugmented design and functional evaluation of low damage implantable array electrodes

doi: 10.1016/j.bioactmat.2024.12.033

Figure Lengend Snippet: Evaluation of the in vivo electrophysiological performance of the electrodes. A) Photograph of the bio-augmented neural microfilament array electrode implanted in brain of mice. B) Single-channel recording of LFP spectrogram using bio-array electrodes (Signal sampling rate of 2K/s, filter range 0.3–300Hz). C) Different rhythmic distributions of LFP signals recorded by bio-array electrodes. D) Comparison of the number of acute neuronal recordings between bio-array and metal array electrodes (Filter range of 500–7500Hz, sampling rate of 30K/s). E) Recording conditions for spike signals in different channels: i) with bio-array, and ii) metal array electrodes. (Bio-array electrodes: bioaugmented array of implantable electrodes; Metal array electrodes: metal array of implantable electrodes). (n = 3; error bars represent standard deviation; Tukey's multiple comparisons test, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001).

Article Snippet: Electrophysiological signals from electrodes were collected using a neural electrode electrophysiological signal acquisition system (Zeus 128-channel system, Nanjing Bio-signal, China), which allows for high-precision surgical implantation of electrodes in small animals and comprehensive monitoring of acute/chronic signals across 128 channels.

Techniques: In Vivo, Sampling, Comparison, Standard Deviation

Journal: Bioactive Materials

Article Title: Bioaugmented design and functional evaluation of low damage implantable array electrodes

doi: 10.1016/j.bioactmat.2024.12.033

Figure Lengend Snippet: Long-term evaluation of the in vivo electrophysiological performance of the electrodes (Acquisition frequency of 30 kHz, bandpass filtering frequency range of 500∼7500Hz). A) Schematic diagram of long-term signal recording from neural electrodes. B) Comparison of spike rates between bio-array electrodes and metal array electrodes. C) Average SNR of LFP signals at different time points for both array electrodes. D) Principal component analysis of unit potentials (spikes) recorded from both array electrodes over 10–60 days post-implantation: i) bio-array electrodes, and ii) metal array electrodes. (Closed circles represent the centers, and ellipses indicate the two standard deviation (2σ) contours of the principal component distribution). E) Average SNR of action potentials at different time points for both array electrodes. F) Number of channels and neurons capable of recording spike signals at different times: i) and number of spike signals that can be recorded over time. ii) for both electrodes. (Bio-arrays: bioaugmented array of implantable electrodes; Metal arrays: metal array of implantable electrodes). (n = 16; error bars represent standard deviation).

Article Snippet: Electrophysiological signals from electrodes were collected using a neural electrode electrophysiological signal acquisition system (Zeus 128-channel system, Nanjing Bio-signal, China), which allows for high-precision surgical implantation of electrodes in small animals and comprehensive monitoring of acute/chronic signals across 128 channels.

Techniques: In Vivo, Comparison, Standard Deviation